Effects of branched-chain amino acid supplementation on nutritional status in cancer patients: protocol for a systematic review and meta-analysis of randomized clinical trials
Keywords:
Branched-chain amino acids, Nutritional status, Cancer, Mortality, Inflammation, Meta-AnalysisAbstract
Introduction: Cancer is a growing public health problem in the world. Poor nutrition is one of the factors that significantly influences the worsening of the disease's prognosis, prolonged treatment and reduced quality of life. Branched-chain amino acids (BCAAs) may influence various tumor phenotypes and play a role as a marker of neoplastic pathology. This study aimed to conduct a systematic review of randomized clinical trials (RCTs) to assess whether BCAA supplementation pre-, peri and post-oncological treatment brings benefits to the clinical outcomes and nutritional status of patients diagnosed with cancer.
Methods: Our review will encompass all RCTs, without publication date limitations, that are published in English, Portuguese, or Spanish and examine the impact of BCAAs on nutritional status in cancer patients. Studies will be sourced from databases such as PubMed, Web of Science, Embase, and SciELO. To be eligible, studies must include adults, involve oral supplementation of BCAAs, not limited to any dosage or duration, feature a control group, and assess outcomes such as clinical outcomes and nutritional status, such as quality of life, inflammation biomarkers, mortality, and lean mass. The Risk of Bias 2.0 will be employed to evaluate the risk of bias, and the PEDro scale will be applied to assess the quality of evidence. Statistical analyses will be conducted using JASP for Windows.
Discussion: This systematic review and meta-analysis included RCTs that evaluated the effects of BCAA supplementation in cancer patients and may contribute to the advancement of knowledge in Nutrition in oncology.
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